Institut für Transfusionsmedizin und Immunhämatologie
Frankfurt am Main
Prof. Dr. med. Dr. med. habil. Michael Schmidt

Abteilung
Bereichsleiter im Spenderscreening
Leiter der Qualitätskontrolle

Beruflicher Werdegang

1992 - 1998
Studium Humanmedizin
Westfälische Wilhelms Universität Münster
 
1998
Promotion zum Dr. med. Universität Münster
 
2000
Approbation Arzt
 
1998 - 2000
Assistenzarzt Innere Medizin Universität Münster
 
2000 - 2002
Facharzt für Arbeitsmedizin
Institut für Arbeitsmedizin Gütersloh
 
2002 - 2012
DRK Blutspendedienst Baden-Württemberg - Hessen
 
2006
Abteilungsleiter Spenderscreening
 
2007
Habilitation Transfusionsmedizin an der Goethe Universität Frankfurt
 
2009
Bereichsleiter Spenderscreening
 
2010 - 2012
Arzt im MV Blutspendedienst
(Betriebsstättennummer: 409459300)
 
2010
Facharzt für Transfusionsmedizin
 
2012
Apl-Professor in Transfusionsmedizin
 
2012 - 2014
Leitung der Geschäftsstelle DGKL / Stiftungsvorstand
 
2014
DRK Blutspendedienst Baden-Württemberg - Hessen
Leiter der Qualitätskontrolle
 

Ausgesuchte Publikationen

  • Kaiser T, Zeuzem S, Lichtinghagen R, Welker MW, Geilemnkeuser WJ, Kruse R, Neumaier M, Thiery J and Schmidt M. Multicenter proficiency test for Lab-MELD score diagnostics to improve the quality and safety for patients awaiting liver transplantation. Clin Chem Lab Med. 2014.
  • Schmidt M, Geilenkeuser WJ, Sireis W, Seifried E, Hourfar KM. Emerging pathogens – How Safe is Blood?. Transfus Med Hemother. 2014 Feb;41(1):10-17.
  • Hahn S, Sireis W, Hourfar K, Karpova D, Dauber K, Kempf VA, Seifried E, Schmidt M, Bönig H. Effects of storage temperature on hematopoietic stability and microbial safety of BM aspirates. Bone Marrow Transplant. 2014 Mar;49(3):338-48.
  • Gubbe K, Scharnagl Y, Grosch S, Tonn T, Schmidt M, Hourfar KM, Karl A, Seifried E, Wilkemeyer I, Kalus U. Validation of Virus NAT for HIV, HCV, HBV and HAV Using Post-Mortal Blood Samples. Transfus Med Hemother. 2012 Dec;39(6):381-5.
  • Schuttrumpf J, Hourfar MK, Alesci S, Miesbach W, Seifried E, Schmidt M: No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 2013;40:32-35.
  • Allering L, Jost H, Emmerich P, Gunther S, Lattwein E, Schmidt M, Seifried E, Sambri V, Hourfar K, Schmidt-Chanasit J: Detection of usutu virus infection in a healthy blood donor from south-west germany, 2012. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2012;17
  • Mueller MM, Hourfar MK, Huber E, Sireis W, Weichert W, Seifried E, Tonn T, Schmidt M: Oxygen measurements in platelet fluids - a new non-invasive method to detect bacterial contaminations in platelets. Transfus Med 2012;22:211-216.
  • Bonig H, Schmidt M, Hourfar K, Schuttrumpf J, Seifried E: Sufficient blood, safe blood: Can we have both? BMC medicine 2012;10:29.
  • Sireis W, Hourfar MK, Seifried E, Schmidt M: How to improve blood safety with respect to bacterial contaminations? Vox sanguinis 2012;103:87-88.
  • Muller MM, Fraile MI, Hourfar MK, Peris LB, Sireis W, Rubin MG, Lopez EM, Rodriguez GT, Seifried E, Saldanha J, Schmidt M: Evaluation of two, commercial, multi-dye, nucleic acid amplification technology tests, for hbv/hcv/hiv-1/hiv-2 and b19v/hav, for screening blood and plasma for further manufacture. Vox sanguinis 2013;104:19-29.
  • C. Geisen, M. Schmidt, D. Klarmann, J. Schüttrumpf, M.M. Müller, E. Seifried. Blut – eine Besondere Ressource. Anästhesiol Intensivmed Notfallmed Schmerzther 2012; 47: 398–407
  • M. Schmidt, W Sireis, E Seifried, X.D. Nguyen, H. Klüter, R. Lofti, H Schrezenmeier. Sicherheit der Blutprodukte – update 2011. Transfusionmedizin 2011;1:1-22.
  • M. Schmidt, W. Sireis and E. Seifried. Implementation if bacterial detection methods into blood donor screening – overview of different technologies. Transfus Med Hemother 2011;38:259-265
  • G. Walther-Wenke, M. Schmidt. Impact of Bacterial Contamination on Blood Supply. Transfus Med Hemother 2011;38:229-230
  • Stormer, M., Arroyo, A., Brachert, J., Carrero, H., Devine, D., Epstein, J. S., Gabriel, C., Gelber, C., Goodrich, R., Hanschmann, K. M., Heath, D. G., Jacobs, M. R., Keil, S., de Korte, D., Lambrecht, B., Lee, C. K., Marcelis, J., Marschner, S., McDonald, C., McGuane, S., McKee, M., Muller, T. H., Muthivhi, T., Pettersson, A., Radziwon, P., Ramirez-Arcos, S., Reesink, H. W., Rojo, J., Rood, I., Schmidt, M., Schneider, C. K., Seifried, E., Sicker, U., Wendel, S., Wood, E. M., Yomtovian, R. A., Montag, T. Establishment of the first International Repository for Transfusion-Relevant Bacteria Reference Strains: ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria Vox Sanguinis early online 2011
  • M. Schmidt and E Seifried. Current concepts in serological testing – TTID. Vox Sanguinis 2011;6:61-66 [IP = 2,585]
  • N Avent, C Sureau, JJ Lefrère, M Schmidt and JP Cartron. White book Transfusion medicine Chapter 4 Blood testing: development of new technologies
  • Walid Sireis, Brigitte Rüster, Charlotte Daiss, Michael Kai Hourfar, Gianni Capalbo, Hans-Ulrich Pfeiffer, Karin Janetzko, Meike Goebel, Volkhard A. J. Kempf, Erhard Seifried and Michael Schmidt Extension of platelet shelf life from four days to five days again by implementation of a new screening strategy in Germany Vox Sanguinis early online 2011 [IP = 2,585]
  • M. Schmidt, XD Nyguen, MK Hourfar, H. Klüter, MM Müller, W Sireis und E Seifried. Nebenwirkung bei der Anwendung von Blutprodukten. Hämotherapie 2010 Ausgabe 14
  • Erhard Seifried und Michael Schmidt. Transfusionsvirologie. Medizinische Virologie 2. Auflage, Thieme Verlag 2010, ISBN 978-3-13-113962-7
  • Michael Schmidt, Erhard Seifried. Improving blood donor screening by nucleic acid technology (NAT). Vox Sanguinins Science Series 2010 Vol 5, 219-229 [IP = 2,585]
  • Michael Kai Hourfar, Uschi Mayr-Wohlfart, Anna Themann, Walid Sireis, Erhard Seifried, Hubert Schrezenmeier and Michael Schmidt. Infectivity of B19 DNA positive blood products Tranfusion (accepted 2010) [IP = 2,982]
  • Reesink HW, Panzer S, Wendel S, Levi JE, Ullum H, Ekblom-Kullberg S, Seifried E, Schmidt M, Shinar E, Prati D, Berzuini A, Ghosh S, Flesland Ø, Jeansson S, Zhiburt E, Piron M, Sauleda S, Ekermo B, Eglin R, Kitchen A, Dodd RY, Leiby DA, Katz LM, Kleinman S. The use of malaria antibody tests in the prevention of transfusion-transmitted malaria. Vox Sang. 2010 Apr;98(3 Pt 2):468-78. Epub 2010 Jan 28.
  • Klose T, Prokoph B, Seidel K, Schmidt M, Hourfar K, Putzker M. Safe system for transport of blood samples at recommended temperature (2-8°C). Clin Lab 2009;55:375-378 [IP = 1,523]
  • Putzker M, Seidel K, Schmidt M, Hourfar K, Friedrich I, Bohnen H, Klose T. Temperautre-stable transport of blood products across europe on varying enviromental demand: Finally working with fresh frozen plasma (FFP) as wel Clin Lab 2009;55:371-374 [IP 1,523]
  • Walther-Wenke G, Schrezenmeier H, Deitenbeck R, Geis G, Burkhart J, Höchsmann B, Sireis W, Schmidt M, Seifried E, Gebauer W, Liebscher UM, Weinauer F, Müller TH. Screening of platelet concentrates for bacterial contamination: spectrum of bacteria detected, proportionof transfused units, and clinical follow-up. Ann Hematol. 2009 May 30. [Epub ahead of print]
  • Schmidt M, Spengler HP, Lambrecht B, Hourfar MK, Seifried E, and Tonn T. A new one platform flow cytometric method for residual cell counting in platelet concentrates. Transfusion 2009;49:2604-11. [IP = 2,982]
  • Schmidt M. Comparison of different methods of bacterial detection in blood components. Vox Sanguinis 2009; 4 (Supp 1):80-86 [IP = 2,585]
  • Schmidt M, Pichl L, Jork C, Hourfar MK, Schottstedt V, Wagner FF, Seifried E, Müller TH, Bux J, and Saldanha J. Blood donor screening with cobas s201/cobas taqscreen mpx under real life conditions at German Red Cross Institutes. Vox Sanguinis, 2010;98:37-46. [IP = 2,585]
  • Schmidt M, Korn K, Nübling CM, Chudy M, Kress J, Horst HA, Geusendam G, Hennig H, Sireis W, Rabenau HF, Doerr HW, Berger A, Hourfar MK, Gubbe K, Karl A, Fickenscher H, Tischer BK, Babiel R, Seifried E, and Gürtler L. First transmission of HIV-1 by a cellular blood product after mandatory nucleic acid screening in Germany. Transfusion 2009;49:1836-44. (IP = 2,982]
  • Hitziger T, Schmidt M, Schottstedt V, Hennig H, Schumann A, Ross S, Lu M, Seifried E, and Roggendorf M. Cellular immune response to hepatitis C virus (HCV) in nonviremic blood donors with indeterminate anti-HCV reactivity. Transfusion 2009 [IP = 2,982]
  • Oliver Karo, Alexandra Wahl, Sven-Boris Nicol, Julia Brachert, Bernd Lambrecht, Hans-Peter Spengler, Frans Nauwelaers, Michael Schmidt, Christian K. Schneider, Thomas H. Müller and Thomas Montag. Bacteria detection by flow cytometry Clin Chem Lab Med 2008;46(7):947–953
  • Hourfar MK, Walch LA, Geusendam G, Dengler T, Janetzko K, Gubbe K, Frank K, Karl A, Löhr M, Sireis W, Seifried E, Schmidt M. Sensitivity and specificity of anti-HBc screening assays – which assay is best for blood donro screening? Int J Lab Hematol 2008, 30.
  • Candotti D, Grabarczyk P, Ghiazza P, Roig R, Casmitjana M, Iudicone P, Schmidt M, Bird A, Crookes R, Broijer E, Miceli M, Amiri A, Li C, Allain JP. Characterization of occult hepatitis B virus from blood donors carrying genotype A2 or genotype D strains. J Hepatol 2008, 49(4):537-547.
  • Pfleiderer C, Blümel J, Schmidt M, Roth WK, Hourfar MK, Eckert J, Chudy M, Menichetti E, Lechner S, Nübling CM. West Nil Virus and blood product safety in Germany. J Med Virol 2008, 80 (3):557-563.
  • Hourfar MK, Jork C, Schottstedt V, Weber-Schehl M, Brixner V, Busch MP, Geusendam G, Gubbe K, Mahnhardt C, Mayr-Wohlfart U, Pichl L, Roth WK, Schmidt M, Seifreid E, Wright DJ. Experience of German Red Cross blood donor service with NAT. Transfusion 2008; 48(8):1558-1566. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Hourfar MK, Themann A, Eickmann M, Puthavathana, Laue T, Seifried E and Schmidt M. Blood screening for influenza.Emerging infectious diseases 2007;13(7): 1081-83. ISI Journal Citation Report Ranking: 5/47 Infectious diseases IF = 5,094
  • Hourfar MK, Koller M, Roth WK, Kehrli R, Seifried E, Schmidt M. Balance module allows consistent monitoring and documentation of the pooling process for nucleic acid amplification technology testing. Vox Sang 2007;93(1):37-41. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Schrezenmeier H, Walther-Wenke G, Muller TH, Weinauer F, Younis A, Holland-Letz T, Geis G, Asmus J, Bauerfeind U, Burkhart J, Deitenbeck R, Forstemann E, Gebauer W, Hochsmann B, Karakassopoulos A, Liebscher UM, Sanger W, Schmidt M, Schunter F, Sireis W, Seifried E. Bacterial contamination of platelet concentrates: results of a prospective multicenter study comparing pooled whole blood-derived platelets and apheresis platelets. Transfusion 2007;47(4):644-52. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Schmidt M, Themann A, Drexler C, Bayer M, Lanzer G, Menichetti E, Lechner S, Wessin D, Prokoph B, Allain JP, Seifried E, Kai Hourfar M. Blood donor screening for parvovirus B19 in Germany and Austria. Transfusion 2007;47(10):1775-82. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Schmidt M, Karakassopoulos A, Burkhart J, Deitenbeck R, Asmus J, Muller TH, Weinauer F, Seifried E, Walther-Wenke G. Comparison of three bacterial detection methods under routine conditions. Vox Sang 2007;92(1):15-21. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Pietersz RN, Engelfriet CP, Reesink HW, Wood EM, Winzar S, Keller AJ, Wilson JT, Henn G, Mayr WR, Ramirez-Arcos S, Goldman M, Georgsen J, Morel P, Herve P, Andeu G, Assal A, Seifried E, Schmidt M, Foley M, Doherty C, Coakley P, Salami A, Cadden E, Murphy WG, Satake M, de Korte D, Bosnes V, Kjeldsen-Kragh J, McDonald C, Brecher ME, Yorntovian R, Aubuchon JP. Detection of bacterial contamination of platelet concentrates. Vox Sang 2007;93(3):260-77. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Pfleiderer C, König C, Chudy M, Schmidt M, Roth WK, Nübling CM. Molecular epidemiology of West Nile Virus in humans. Dev biol (Basel) 2006;126:197-201.
  • Brixner V, Mosebach M, Schmidt M, Hermann S, Seifried E, Martin H, Seidl C. HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin. Tissue Antigens 2006;67(2):160-2. ISI Journal Citation Report Ranking: 88/156 Cell biology; IF = 2,462
  • Chudy M, Schmidt M, Czudai V, Scheiblauer H, Nick S, Mosebach M, Hourfar MK, Seifried E, Roth WK, Gruenelt E and Nuebling CM. First case of HBV genotype G mono-infection and its transmission by blood components. Hepatology 2006;44:99-107. ISI Journal Citation Report Ranking: 2/48 Gastro. & Hepatology; IF = 10,446 (Chudy and Schmidt contributed equally to this paper)
  • Schmidt M, Hourfar MK, Nicol SB, Wahl A, Heck J, Weis C, Tonn T, Spengler HP, Montag T, Seifried E, Roth WK. A comparison of three rapid bacterial detection methods under simulated real-life conditions. Transfusion 2006; 46(8):1367-73. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Schmidt M, Heck J, Weis C, Montag T, Nicol SB, Seifried E. Scansystem™ Enables Rapid and Sensitive Bacterial Detection in Platelets Stored in Additive Solution with Implementation of Standard Positive Control Capsules. Transfus Med Hemother 2006;33(3):274-278. ISI Journal Citation Report Ranking: 58/61 Hematology; IF = 0,598
  • Schmidt M, Nicol SB, Spengler HP, Montag T, Seifried E. FACS technology used in a new rapid bacterial detection method. Transfusion Medicine 2006, 16(5): 355-61. ISI Journal Citation Report Ranking: 41/61 Hematology; IF = 1,634
  • Schmidt M, Wahl A, Nicol SB, Montag T, Roth WK, Seifried E. Fluorescence quencher improves Scansystem for rapid bacterial detection. Vox Sang 2006; 90(4):276-278. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Schmidt M, Roth WK, Seifried E, Hourfar MK. Donor screening for agents of bioterror. Transfusion 2006;46(4):678-9. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Hourfar MK, Michelsen U, Schmidt M, Berger A, Seifried E and Roth WK. High-throughput purification of viral RNA based on novel aqueous chemistry for nucleic acid isolation. Clin Chem 2005;51(7):1217-22. ISI Journal Citation Report Ranking: 2/25 Medical Laboratory Technology; IF = 5,454
  • Hourfar MK, Schmidt M, Seifried E, Roth WK. Evaluation of an automated high-volume extraction method for viral nucleic acids in comparison to a manual procedure with preceding enrichment. Vox Sang 2005;89(2):71-6. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Schmidt M, Roth WK, Meyer H, Seifried E and Hourfar MK. Nucleic acid test screening of blood donors for orthopoxviruses can potentially prevent dispersion of viral agents in case of bioterrorism. Transfusion 2005;45(3):399-403. ISI Journal Citation Report Ranking: 14/62 Hematology; IF = 3,708
  • Schmidt M, Weis C, Heck J, Montag T, Nicol SB, Hourfar MK, Schaefer V, Sireis W, Roth WK and Seifried E. Optimized Scansystem platelet kit for bacterial detection with enhanced sensitivity: detection within 24 h after spiking. Vox Sang 2005;89(3):135-9. ISI Journal Citation Report Ranking: 34/61 Hematology; IF = 2,111
  • Schmidt M, Weber M, Busch MP, Tobler LH, Phelps BH, Seifried E and Roth WK. Yield of hepatitis C virus nucleic acid testing among antibody-reactive or confirmed-positive samples. Transfusion 2005;45(6):1040-2. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Hourfar MK, Roth WK, Seifried E, Schmidt M. Comparison of two real-time quantitative assays for detection of severe acute respiratory syndrome coronavirus. J Clin Microbiol 2004;42(5):2094-100. ISI Journal Citation Report Ranking: 21/89 Microbiology; IF = 3,445
  • Gockel HR, Lugering A, Heidemann J, Schmidt M, Domschke W, Kucharzik T and Lugering N. Thalidomide induces apoptosis in human monocytes by using a cytochrome c-dependent pathway. J Immunol 2004;172(8):5103-9. ISI Journal Citation Report Ranking: 11/117 Immunology; IF = 6,293
  • Schmidt M, Brixner V, Ruster B, Hourfar MK, Drosten C, Preiser W, Seifried E and Roth WK. NAT screening of blood donors for severe acute respiratory syndrome coronavirus can potentially prevent transfusion associated transmissions. Transfusion 2004;44(4):470-5. ISI Journal Citation Report Ranking: 19/61 Hematology; IF = 3,278
  • Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W and Kucharzik T. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 2001;121(5):1145-57. ISI Journal Citation Report Ranking: 1/48 Gastroenterology; IF = 12,457 (Lugering and Schmidt contributed equally to this paper)
  • Schmidt M, Lugering N, Lugering A, Pauels HG, Schulze-Osthoff K, Domschke W and Kucharzik T. Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis. J Immunol 2001;166(2):1344-51. ISI Journal Citation Report Ranking: 11/117 Immunology; IF = 6,293
  • Schmidt M, Lugering N, Pauels HG, Schulze-Osthoff K, Domschke W and Kucharzik T. IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway. Eur J Immunol 2000;30(6):1769-77. ISI Journal Citation Report Ranking: 17/117 Immunology; IF = 4,772
  • Lang D, Hubrich A, Dohle F, Terstesse M, Saleh H, Schmidt M, Pauels HG and Heidenreich S. Differential expression of heat shock protein 70 (hsp70) in human monocytes rendered apoptotic by IL-4 or serum deprivation. J Leukoc Biol 2000;68(5):729-36. ISI Journal Citation Report Ranking: 12/61 Hematology; IF = 4,572
  • Schmidt M, Dercken C, Loke O, Reimann S, Diederich S, Blasius S and Heidenreich S. Pulmonary manifestation of systemic mast cell disease. Eur Respir J 2000;15(3):623-5. ISI Journal Citation Report Ranking: 3/34 Respiratory systems; IF = 5,076
  • Schmidt M, Pauels HG, Lugering N, Lugering A, Domschke W and Kucharzik T. Glucocorticoids induce apoptosis in human monocytes: potential role of IL-1 beta. J Immunol 1999;163(6):3484-90. ISI Journal Citation Report Ranking: 11/117 Immunology; IF = 6,293
  • Heidenreich S, Schmidt M, August C, Cullen P, Rademaklers A and Pauels HG. Regulation of human monocyte apoptosis by the CD14 molecule. J Immunol 1997;159(7):3178-88. ISI Journal Citation Report Ranking: 11/117 Immunology; IF = 6,293
  • Heidenreich S, Sato T, Schmidt M, August C, Timmerman JJ, van Es LA and Daha MR. Induction of mesangial interleukin-6 synthesis by apoptotic U937 cells and monocytes. Kidney Int 1997;52(2):318-28. ISI Journal Citation Report Ranking: 3/55 Urology/Nephrology; IF = 4,773
  • Heidenreich S, Otte B, Lang D, Schmidt M. Infection by Candida albicans inhibits apoptosis of human monocytes and monocytic U937 cells. J Leukoc Biol 1996;60(6):737-43. ISI Journal Citation Report Ranking: 12/61 Hematology; IF = 4,572
  • Heidenreich S, Schmidt M, Bachmann J, Harrach B. Apoptosis of monocytes cultured from long-term hemodialysis patients. Kidney Int 1996;49(3):792-9. ISI Journal Citation Report Ranking: 3/55 Urology/Nephrology; IF = 4,773
  • Heidenreich S, Kubis T, Schmidt M, Fegeler W. Glucocorticoid-induced alterations of monocyte defense mechanisms against Candida albicans. Cell Immunol 1994;157(2):320-7. ISI Journal Citation Report Ranking: 89/117 Immunology; IF = 1,709



Prof. Dr. med. Dr. med. habil.
Michael Schmidt

Oberarzt
Bereichsleiter im Spenderscreening
Leiter der Qualitätskontrolle

Institut Frankfurt am Main
Sandhofstrasse 1
60528 Frankfurt
Tel.: 069 / 6782-241
Fax.: 069 / 6782-257

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