Institut für Transfusionsmedizin und Immunhämatologie
Frankfurt am Main
Prof. Dr. med. Christian Seidl

Transplantationsimmunologie und Immungenetik

Beruflicher Werdegang
Medizinstudium an der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main
Fellowship am Lindslay F. Kimball Research Institute, New York, USA
Clinical Research Fellowship am Memorial Sloan-Kettering Cancer Center in New York, USA
Klinische Weiterbildung in Innerer Medizin (Nephrologie, Hämatologie / Onkologie) und Transfusionsmedizin, Johann-Wolfgang Goethe-Universitätsklinikum, Frankfurt am Main
Habilitation in Experimenteller Hämatologie
Facharzt für Transfusionsmedizin

Mitgliedschaften in wissenschaftlichen Fachgesellschaften

  • Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatology (DGTI)
  • Deutsche Gesellschaft für Immungenetik (DGI)
  • Deutsche Transplantationsgesellschaft (DTG)
  • European Federation for Immunogenetics (EFI)
  • International Society for Forensic Haemogenetics (ISFH)
  • American Society for Histocompatibility (ASHI)
  • New York Academy of Sciences (NYAS)


  • Projekt - EU-Q-Blood-SOP‚ Konzeption eines pan-europäischen SOP-basierten Qualitätsmanagementsystems (EU-Q-Blood-SOPt) für den Bereich der Transfusionmedizin’
  • Projekt EuBIS (EU-Blood-Inspection), Europäische Qualitätsmanagement- und Inspektions-Standards für Blutspendeeinrichtungen in Zusammenarbeit mit der Europäischen Kommission, Directorate General SANCO.
  • Projekt Klinische Forschergruppe - Chimärismus, Autoimmunität und Toleranzinduktion durch Transplantation hämatopoetischer Stammzellen

Ausgesuchte Publikationen

  • Seidl C, Körbitzer J, Badenhoop K, Seifried E, Hoelzer D, Zanelli E, Kaltwasser JP. Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among rheumatoid arthritis patients carrying the HLA-DQ3-DR4 and HLA-DQ5-DR1 haplotypes.
    Hum Immunol 2001; 62: 523-529.
  • Willenbrock K, Roers A, Seidl C, Wacker H-H, Küppers R, Hansmann M-L. Analysis of T-cell subpopulations in T-cell non-Hodkin’s lymphoma of AILD type by single target gene amplification of T-cell receptor beta gene rearrangements.
    Am J Clin Pathol 2001; 158: 1851-1857.
  • Donner H, Seidl C, Rau H, Herwig J, Seifried E, Usadel KH, Badenhoop K.
    Unbalanced amounts of HLA-DQA1 allele mRNA: DQA1*03 shows high and DQA1*0501 low amounts of mRNA in heterozygous individuals.
    Eur J Immunogenet. 2002; 29(4):321-30.
  • Bieda K, Pani MA, van der Auwera B, Seidl C, Tönjes RR, Gorus F, Usadel KH, Badenhoop K. A novel retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I (insulin-dependent) diabetes susceptibility on high risk DQ haplotypes.
    Diabetologia 2002; 45(3): 443-447.
  • Pani MA, Seidl C, Bieda K, Krause M, Seifried E, Usadel KH, Badenhoop K. Preliminary evidence that an endogenous retroviral long terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison’s disease.
    Clin Endocrinol 2002; 56(6): 773-777.
  • Koehl U, Beck O, Esser R, Seifried E, Klingebiel T, Schwabe D, Seidl C. Quantitative analysis of chimerism after allogeneic cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Frankfurt experience.
    Leukemia 2003; 17(1): 232-236.
  • Becker S, Tonn T, Füssel T, Uhrberg M, Seifried E, Seidl C. Assessment of Killer Cell Immunoglobulin-like Receptor (KIR) expression and corresponding HLA-class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA-class I ligands.
    Hum Immunol 2003; 64(2): 183-193.
  • Badenhoop K, Seidl C. Fine tuning of T-lymphocytes in autoimmunity: genetic association of CTLA-4 variants and Graves disease revisited.
    Clin Endocrinol 2003; 59(5): 555-557.
  • Steinborn A, Seidl C, Sayehli C, Sohn C, Seifried E, Schmitt E. Anti-fetal immune response mechanisms may be involved in the pathogenesis of placental abruption.
    Clin Immunol 2004; 110(1): 45-54.
  • Koehl U, Sörensen J, Esser R, Zimmermann S, Grüttner HP, Tonn T, Seidl C, Seifried E, Klingebiel Th, Schwabe D. IL-2 activated NK cell immunotherapy in three children after haploidentical stem cell transplantation.
    Blood Cells Mol Dis. 2004; 33(3): 261-266
  • Koehl U, Esser R, Zimmermann S, Sörensen J, Grüttner HP, Martin H, Kotchetkov R, Bartling T, Lang P, Tonn T, Seidl C, Seifried E, Klingebiel Th, Schwabe D. Clinical scale selected and expanded CD56+ CD3- donor cells for immunotherapy.
    Immunology 2004: 407-415.
  • Hauser IA, Schaeffeler E, Gauer S, Scheuermann EH, Wegner B, Gossmann J, Ackermann H, Seidl C , Hocher B, Zanger UM, Geiger H, Eichelbaum H, Schwab M. ABCB1 Genotype of the Donor but Not of the Recipient Is a Major Risk Factor for Cyclosporine-Related Nephrotoxicity after Renal Transplantation.
    J Am Soc Nephrol. 2005;16(5):1501-11.
  • Steinborn A, Schmitt E, Stein Y, Klee A, Gonser M, Seifried E, Kaufmann M, Seidl C. Prolonged preterm rapture of the fetal membranes, a consequnce of an increased maternal anit-fetal T-cell response.
    Pediatr Res. 2005 ;58(4):648-53.
  • Ramos-Lopez E, Kurylowicz A, Bednarczuk T, Paunkovic J, Seidl C, Badenhoop K. Vitamin D receptor polymorphisms are associated with Graves’ disease in German and Polish but not in Serbian patients.
    Thyroid 2005; 15(10): 1125-30.
  • Beck O, Seidl C, Kreyenberg H, Lehrnbecher T, Schwabe D, Klingebiel Th, Seifried E, Bader P, Koehl U. Quantification of mixed chimerism within peripheral blood, bone marrow and purified leukocyte subsets: Comparison between singleplex versus multiplex PCR amplification of short tandem repeat (STR) loci. Eur J Haematol. 2006 ;76(3):237-44. QB and CS have contributed equally to this sudy
  • Mosebach M, Brixner V, Bader P, Klingebiel Th, Seifried E, Seidl C. Intergenic recombination with HLA-C leads to a novel HLA-A*19 allele, HLA-A*2910, that is characterised by a functionally inactive amino acid exchange in the loop connecting the α2 and α3 domains.
    Tissue Antigens 2006 ;67(1):75-8.

Prof. Dr. med.
Christian Seidl Abteilungsleiter

Institut Frankfurt am Main
Sandhofstrasse 1
60528 Frankfurt
Tel.: 069-6782-232 / 203
Fax.: 069-6782-254